We reported islet amyloidosis in a 12.5-year old Caucasian female with type 1 diabetes for 2 years, representing the youngest human reported with this finding. Islet amyloidosis was considered pathognomonic for type 2 diabetes but histopathological studies from the nPOD biorepository show its presence in young donors with type 1 diabetes. Understanding how beta-cell stress is either compensated or dysregulated will provide for effective diabetes prevention and therapeutic strategies.
Beery ML, Jacobsen LM, Atkinson MA, Butler AE, Campbell-Thompson M. Islet amyloidosis in a child with type 1 diabetes. 2019;11(2):44-49. doi: 10.1080/19382014.2019.1599707. Epub 2019 May 14. PubMed PMID: 31084520; PubMed Central PMCID: PMC6548483.