All Posts by

Martha Campbell-Thompson

Exocrine pancreas in the limelight

Investigators met at NIH to discuss exocrine-endocrine interactions in the pancreas and their findings are available in the March 20, 2023 issue of Diabetes. Dr. Campbell-Thompson spoke on the loss of acinar cell mass in the natural history of type 1 diabetes.

3D imaging of human pancreatic cell cultures- Biomedical Image of the Day

Studies using acinar cells from islet donors are shedding light on mechanisms of acinar-ductal metaplasia (ADM). ADM is a precursor lesion of pancreatic ductal adenocarcinoma. Following several days in 3D culture conditions using Matrigel, duct-like structures are observed using multiplex immunofluorescence. One of the images was selected in Biomedical Image…

Case Report: Youngest Person with Islet Amyloidosis

We reported islet amyloidosis in a 12.5-year old Caucasian female with type 1 diabetes for 2 years, representing the youngest human reported with this finding. Islet amyloidosis was considered pathognomonic for type 2 diabetes but histopathological studies from the nPOD biorepository show its presence in young donors with type 1…

Optical clearing and 3D high resolution imaging human islets

Recently published paper with Drs. Tang, Jessup and Campbell-Thompson delineates islet innervation in humans. Sympathetic fibers (TH+) were observed in islets from controls and patients with T1D and the TH+ fibers coursed adjacent to α-cells in addition to following the islet microvasculature. Our islet innervation studies were also presented at…