Investigators met at NIH to discuss exocrine-endocrine interactions in the pancreas and their findings are available in the March 20, 2023 issue of Diabetes. Dr. Campbell-Thompson spoke on the loss of acinar cell mass in the natural history of type 1 diabetes.
Studies using acinar cells from islet donors are shedding light on mechanisms of acinar-ductal metaplasia (ADM). ADM is a precursor lesion of pancreatic ductal adenocarcinoma. Following several days in 3D culture conditions using Matrigel, duct-like structures are observed using multiplex immunofluorescence. One of the images was selected in Biomedical Image…
Recent publication in Nature Communications with Ben Giepmans utilizing his state-of-the-art Zeiss EM microscopy core and online image repository for macromolecular resolution of cells in human islets. DOI: 10.1038/s41467-020-16287-5…
We reported islet amyloidosis in a 12.5-year old Caucasian female with type 1 diabetes for 2 years, representing the youngest human reported with this finding. Islet amyloidosis was considered pathognomonic for type 2 diabetes but histopathological studies from the nPOD biorepository show its presence in young donors with type 1…
Recently published paper with Drs. Tang, Jessup and Campbell-Thompson delineates islet innervation in humans. Sympathetic fibers (TH+) were observed in islets from controls and patients with T1D and the TH+ fibers coursed adjacent to α-cells in addition to following the islet microvasculature. Our islet innervation studies were also presented at…
Recent studies from the lab show decreased islet vessel diameter and increased tortuosity after loss of all beta-cells in a given islet from donors with type 1 diabetes. Link …
Our research is primarily focused on translational studies for restoring beta cell function in Type 1 Diabetes. High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network- Jove 2018, in press. Insulitis and beta cell mass in the natural history of type 1 diabetes…
