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Case Report: Youngest Person with Islet Amyloidosis

We reported islet amyloidosis in a 12.5-year old Caucasian female with type 1 diabetes for 2 years, representing the youngest human reported with this finding. Islet amyloidosis was considered pathognomonic for type 2 diabetes but histopathological studies from the nPOD biorepository show its presence in young donors with type 1…

Optical clearing and 3D high resolution imaging human islets

Recently published paper with Drs. Tang, Jessup and Campbell-Thompson delineates islet innervation in humans. Sympathetic fibers (TH+) were observed in islets from controls and patients with T1D and the TH+ fibers coursed adjacent to α-cells in addition to following the islet microvasculature. Our islet innervation studies were also presented at…

Our Research Focus

Our research is primarily focused on translational studies for restoring beta cell function in Type 1 Diabetes. High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network- Jove 2018, in press. Insulitis and beta cell mass in the natural history of type 1 diabetes…

Our Publications

New study shows proinsulin levels were at near-normal levels and comparable to people without diabetes in pancreata of long-term type 1 diabetes patients. A small number of insulin-positive cells remained as well. These observations raised the question of how these cells avoided destruction by the immune system and whether…