Islet with amyloid from child with type 1 diabetes

Case Report: Youngest Person with Islet Amyloidosis

We reported islet amyloidosis in a 12.5-year old Caucasian female with type 1 diabetes for 2 years, representing the youngest human reported with this finding. Islet amyloidosis was considered pathognomonic […]

TH human islet

Optical clearing and Lightsheet imaging human islets

Recently published paper with Drs. Tang and Jessup delineate islet innervation in humans. Sympathetic fibers (TH+) were observed in islets from controls and patients with T1D and the TH+ fibers […]

Microvasculature Cover

Islet Microvascular is Altered with Loss of Beta-Cells in Patients with Type 1 Diabetes

Recent studies from the lab show decreased islet vessel diameter and increased tortuosity after loss of all beta-cells in a given islet from donors with type 1 diabetes. Link  

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Recent News

Intermediate cells

Large-scale electron microscopy database for human type 1 diabetes

Aug 3rd, 2020

Recent publication in Nature Communications with Ben Giepmans utilizing his state-of-the-art Zeiss EM microscopy core and online image repository for macromolecular resolution  of cells in human islets. DOI: 10.1038/s41467-020-16287-5